Researchers and therapy formulation experts have also tried to improve the properties of CQ by combining it with different ingredients (cf. They also appear efficient for lipase and amylase inhibition, thereby providing a mechanism for weight loss via reduced oxidative stress, dietary fat, and carbohydrate blocking. The unique chemical constituents of CQ–novel flavonoids and indanes, as well as phytosterols and keto-steroids–have shown promise as powerful and efficient antioxidants. Although some studies have examined other uses of CQ, its role in fighting obesity and symptoms of metabolic syndrome has attracted interest in other parts of the world. In accord with this approach are numerous investigations of the effectiveness of medicinal plants as natural supplements in reducing body weight, e.g., Cissus quadrangularis (Linn) and Irvingia gabonensis (Aubry-Lecomte ex O’Rorke).Ĭissus quadrangularis (CQ), a succulent vine native to West Africa and Southeast Asia, has been used in traditional African and Ayurvedic medicine for more than a century. It is not at all surprising to see the marketing of many new dietary slimming aids aimed at satisfying the need for palatable (as well as safe, effective, and therapeutic) options. hence the probability of compliance with conventional weight-management programs, which often include increasing energy expenditure via physical activity, is low. Īmong the many factors responsible for overweight and obesity is the continuing decline in physical activity. In addition to individual pain and suffering, these conditions lead to substantial economic costs in national healthcare budgets. Excess body weight is one of the most important risk factors for all-cause morbidity and mortality i.e., the likelihood of developing such conditions as Type 2 diabetes, heart disease, cancer, and osteoarthritis of weight-bearing joints increases with body weight. ![]() adult population was classified as overweight or obese. As early as 1999–2000, approximately two-thirds of the U.S. The percentage of persons whose body weight is considerably greater than ideal continues to rapidly increase, particularly in the developed countries. This apparently synergistic formulation should prove helpful in the management of obesity and its related complications. ConclusionĪlthough the Cissus quadrangularis- only group showed significant reductions on all variables compared to the placebo group, the Cissus quadrangularis / Irvingia gabonensis combination resulted in even larger reductions. The magnitude of the differences was noticeable by week 4 and continued to increase over the trial period. ResultsĬompared to the placebo group, the two active groups showed a statistically significant difference on all six variables by week 10. A total of six anthropomorphic and serological measurements (body weight, body fat, waist size total plasma cholesterol, LDL cholesterol, fasting blood glucose level) were taken at baseline and at 4, 8 and 10 weeks. Capsules containing the placebo or active formulations were administered twice daily before meals no major dietary changes nor exercises were suggested during the study. The participants were randomly divided into three equal (n = 24) groups: placebo, Cissus quadrangularis-only, and Cissus quadrangularis / Irvingia gabonensis ( African Mango) combination. The study was a 10 week randomized, double-blind, placebo-controlled design involving 72 obese or overweight participants (45.8% male 54.2% female ages 21–44 mean age = 29.3). To evaluate the effects of two formulations, Cissus quadrangularis-only and a Cissus quadrangularis / Irvingia gabonensis (African Mango) combination, on weight loss in overweight and obese human subjects.
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